Therapeutic window of dopamine D2/3 receptor occupancy to treat psychosis in Alzheimer’s disease
نویسندگان
چکیده
منابع مشابه
Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer disease.
OBJECTIVE To examine if selected polymorphisms in the dopamine receptor genes DRD1, DRD2, DRD3, and DRD4 are associated with the presence of psychosis or aggressive behavior in patients with Alzheimer disease (AD). DESIGN A cohort of patients with AD were longitudinally evaluated for behavioral symptoms and classified with regard to the presence of psychotic symptoms and physical aggression. ...
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OBJECTIVE Response to typical antipsychotic medication has been associated with achieving a level of striatal dopamine D2 receptor occupancy in the range of 65% to 70%. We undertook this study to determine whether response to the atypical antipsychotic olanzapine occurs at lower levels of D2 receptor occupancy. METHOD Eighteen patients who presented with a first episode of psychosis were rand...
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The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therap...
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ژورنال
عنوان ژورنال: Brain
سال: 2017
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/aww359